Research output

Publications

Peer-reviewed work spanning targeted protein degradation, covalent chemoproteomics, and small-molecule ion transport.

1. 2025
   Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation

   McMahon EJ, Cioffi AG, Visperas PR, Lin Y, Shaghafi M, Daczkowski CM, Hermann JC, Everley RA, Neve RM, Erlanson DA, Webster KR, Narayan V, Wang W

   Structure 2025, 33, 2020–2028.e7

   DOI PubMed
2. 2021
   Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC

   Boike L, Cioffi AG, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK

   Cell Chemical Biology 2021, 28, 4–13.e17

   DOI PubMed Free full text
3. 2019
   Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia

   Muraglia KA, Chorghade RS, Kim BR, Tang XX, Shah VS, Grillo AS, Daniels PN, Cioffi AG, Karp PH, Zhu L, Welsh MJ, Burke MD

   Nature 2019, 567, 405–408

   DOI PubMed Free full text
4. 2018
   Solid-state NMR of highly ¹³C-enriched cholesterol in lipid bilayers

   Della Ripa LA, Petros ZA, Cioffi AG, Piehl DW, Courtney JM, Burke MD, Rienstra CM

   Methods 2018, 138–139, 47–53

   DOI PubMed Free full text
5. 2017
   Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

   Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD

   Science 2017, 356, 608–616

   DOI PubMed
6. 2016
   Our path to less toxic amphotericins

   Endo MM, Cioffi AG, Burke MD

   Synlett 2016, 27, 337–354 (Account)

   DOI
7. 2015
   C3-OH of amphotericin B plays an important role in ion conductance

   Davis SA, Della Ripa LA, Hu L, Cioffi AG, Pogorelov TV, Rienstra CM, Burke MD

   J. Am. Chem. Soc. 2015, 137, 15102–15104

   DOI PubMed Free full text
8. 2015
   Restored physiology in protein-deficient yeast by a small molecule channel

   Cioffi AG, Hou J, Grillo AS, Diaz KA, Burke MD

   J. Am. Chem. Soc. 2015, 137, 10096–10099

   DOI PubMed Free full text
9. 2014
   Amphotericin forms an extramembranous and fungicidal sterol sponge

   Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD

   Nature Chemical Biology 2014, 10, 400–406

   DOI PubMed Free full text
10. 2011
    Electrochemical oscillations of nickel electrodissolution in an epoxy-based microchip flow cell

    Cioffi AG, Martin RS, Kiss IZ

    J. Electroanal. Chem. 2011, 659, 92–100

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Intellectual property

Patent applications

1. 2019
   Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof

   Burke MD, Grillo AS, Cioffi AG, SantaMaria AM, Blair D, Blake A

   PCT/US2019/027314
2. 2019
   Restoration of transmembrane copper transport

   Burke MD, Nardone C, Blake A, SantaMaria AM, Grillo AS, Cioffi AG, Lyu Y

   PCT/US2019/024340
3. 2015
   Restoring physiology with small molecule mimics of missing proteins

   Burke MD, Cioffi AG, Diaz KA, Hou J, Grillo AS

   PCT/US2015/058806